Web5 jun. 2011 · (a) Targeting strategy for mouse Ifit1. lacZ, gene encoding β-galactosidase; PGK, promoter of the gene encoding phosphoglycerate kinase; neo, neomycin … Web21 mrt. 2024 · An important paralog of this gene is IFIT1. UniProtKB/Swiss-Prot Summary for IFIT5 Gene. ... Promoter/Enhancer: 1.7: EPDnew Ensembl ENCODE CraniofacialAtlas: 284.60: 479.97-21.2: 4: 3.4: SP1 CEBPG BRCA1 YY1 CEBPA ZNF207 CTCF CEBPB ZNF341 IRF2: IFIT5 IFIT1 ENSG00000232110 SLC16A12-AS1 piR-36921-009 LIPA:
Where, in antiviral defense, does IFIT1 fit? Nature Immunology
Web20 jun. 2011 · New data show that the interferon-induced gene product IFIT1 is a sensor for 5′-triphosphorylated RNA of viral origin and that it functions within a larger IFIT complex to inhibit viral... Web15 mrt. 2024 · IFITs typically contain multiple IFN-stimulated response elements (ISREs) in their promoters (reviewed in 3) and are also induced directly by IFN-regulatory factor 3 , downstream of initial PRR activation. ... IFIT1:IFIT2 and IFIT1:IFIT3—1 mg/ml of each protein was mixed and incubated for 1 h at 4 or 30°C. motorhomes pre-owned rvs
IFIT1 - Wikipedia
Web2 okt. 2024 · IFIT1 TLR4 interferon gene program pro-inflammatory gene program RNAi screen TNF-α Introduction Toll-like receptors (TLRs) play a critical role in the innate … Webdriven by truncated Ifit1 promoters, identified the regions that mediate the repression, and a chromatin immunoprecipitation assay revealed that more IRF8 bound to the IFN … Web21 jan. 2014 · Given these results, the Huh7 cells, which serve as the foundation for in vitro HCV virological studies, were used to create a stable cell line harboring the IFIT1 promoter reporter construct. Upon colony selection, clone 22 demonstrated promising sensitivity and specificity to SeV infection or IFN treatment in a dose-dependent manner ( Fig. S1 C – F ). motorhomes preston lancashire