WebGSL, glycosphingolipid; HGF, hepatocyte growth factor; NeuAc, N-acetylneuraminic acid; NeuGc, N-glycolylneuraminic acid; PM, plasma membrane; TGN, trans-Golgi network. 6338 FEBS Journal 280 (2013) 6338–6353 ª 2013 FEBS. accurate molecular description of … WebGlycosphingolipids (GSLs) comprise a heterogeneous group of membrane lipids formed by a ceramide backbone covalently linked to a glycan moiety. Hundreds of different …
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES …
WebThe glycosphingolipid-induced dendritic cell activation requires intact fucose residues on the glycolipids, and is induced via a mechanism that involves both the dendritic cell receptors TLR4 and DC-SIGN. ... Whereas GSL biosynthesis starts at the membranes of the endoplasmic reticulum (ER) and continues on the Golgi membranes, catabolism ... WebSix of these genes function in signaling pathways such as synthesis of glycosphingolipid biosynthesis-lacto and neolacto series. MyoD1 inhibited transcription of fucosyltransferase IV (FUT4) by binding directly to the FUT4 F3; this finding was validated by ChIP-quantitative PCR and a luciferase reporter assay. Ulex europaeus agglutinin I, which ... mahogany office
Differential Regulation of Lacto-/Neolacto- Glycosphingolipid ...
WebJul 2, 2024 · Pathway enrichment showed two common TNBC-enriched pathways across all three datasets, cell cycle and lacto-/neolacto- glycosphingolipid (GSL) biosynthesis, while a total of four glycosylation-related pathways were significantly enriched in TNBC. We applied a selection criterion of the top 50% differential anabolic/catabolic glycogenes in … WebM00070 Glycosphingolipid biosynthesis, lacto-series M00071 Glycosphingolipid biosynthesis, neolacto-series ... WebThis Review details some of the recent findings on the biosynthesis, function, and degradation of glycosphingolipids in man, with a focus on the glycosphingolipid glucosylceramide. Special attention is paid to the clinical relevance of compounds directed at interfering with the factors responsible for glycosphingolipid metabolism. mahogany obsidian sphere