WebMar 23, 2024 · Onconova and Pangea Biomed will chart genetic interactions related to PLK1 to identify a biomarker of response to rigosertib based on its inhibitory activity against this protein. The ENLIGHT... WebPLK1 polo-like kinase 1: ALIAS: PLK1,PLK,STPK13 : LOCUS: 16p: CLASS: Serine/Threonine Kinase GROUP: Other: FAMILY: PLK : UniProt: P53350: OMIM: …
BTN-PLK1 – CarnaBio USA, Inc.
WebMar 13, 2024 · The well-known mitotic regulator polo-like kinase 1 (PLK1) participates in G2/M transition, DNA integrity maintenance, and the overexpression maturation of various organelles [ 9, 10, 11 ]. It has been shown that PLK1 inhibits NF-κB nuclear activation, but the related mechanism is unexplored. WebTo study knockdown effect of small interfering RNA (siRNA) to PLK1 (Polo-like kinase 1) mRNA in colorectal cancer cell line SW480 and its mitosis and growth was changed. Ten special siRNA molecules were designed targeting different sites of PLK1 mRNA sequence and chemically synthesized. underskinning a pontoon boat
PLK1 Gene - GeneCards PLK1 Protein PLK1 Antibody
WebApr 4, 2024 · PLK1 promotes proliferation and suppresses apoptosis of renal cell carcinoma cells by phosphorylating MCM3. PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways. WebMay 13, 2024 · Through an in vitro drug screening, PLK1 or CHEK1 inhibitors (BI-2536 or prexasertib) were found to exert a superior anticancer effect against cell lines at low nanomolar concentrations and induce cell-cycle arrest. In SK-UT-1 tumor-bearing mice, BI-2536 monotherapy remarkably suppressed tumorigenicity. WebAug 11, 2024 · Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential J Med Chem. 2024 Aug 11;65 (15):10133-10160. doi: 10.1021/acs.jmedchem.2c00614. Epub 2024 Jul 25. Authors under skin spot on chin